Inflammatory cardiovascular risk markers and silent myocardial ischemia in type 2 diabetic patients

Background/Aim. A special feature of coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM) is that it often a symptomatic and occurs as consequence cardiovascular autonomic neuropathy. Dysregulation the nervous system associated elevated values inflammatory markers such high-sensitivity C-reactive protein (hs-CRP) interleukin- 6 (IL-6), which accelerate atherosclerosis occurrence complications T2DM. The aim study was to evaluate importance determining risk IL-6 hs-CRP screening for presence CHD asymptomatic Methods. included 169 T2DM without any symptoms signs CHD. Ergometric testing proved or ruled out silent levels hs- CRP were determined by ELISA. Results. significantly higher positive ergometric test (6.83 ? 1.99 pg/mL) compared negative (3.04 1.39 (p < 0.001). We also found (6.37 2.25 vs 1.67 1.41 mg/L; p Combinations age, HbA1c values, duration diabetes, presented through three binary logistic regression models, are significant predictors proven testing, ie, their increase, probability increases 0.01). sensitivity finding detection 90%, specificity 86%. Conclusion. Hs-CRP CHD, determination could be recommended improving stratification